ABOUT Prof. ASHERY
Graduated from the Hebrew University of Jerusalem, I was always fascinated by the mechanism of neuronal function. Specifically I am interested in understanding synaptic plasticity in normal and disease states. Our lab uses multidisciplinary approaches combining electrophysiology, super-resolution and TIRF microscopy, molecular and cellular neurobiology and computer modeling, to study synaptic plasticity and correlate between molecular changes, synaptic function and dysfunction and animal behavior.
Our main focus currently is on the following directions:
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Investigating synaptic plasticity processes at the hippocampal mossy fiber synapses:
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Investigating molecular mechanism of synaptic plasticity.
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Elucidating mechanisms of cAMP dependent synaptic plasticity.
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Correlating synaptic plasticity to learning and memory processes.
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Elucidating the mitigating effects of hyperbaric oxygen treatment (HBOT) in Alzheimer's disease (AD) mouse models:
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Investigating the molecular and cellular mechanisms that are regulated following HBOT in AD mouse models.
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Exploring the physiological effect of HBOT on synaptic activity and plasticity and on blood flow.
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Identifying early biomarkers for Parkinson’s disease (PD):
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Characterizing early steps in alpha-synuclein aggregation.
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Investigating the effect of alpha-synuclein aggregation on neuronal activity.
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We employ a wide range of methods including: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), Super resolution microscopy (STORM, STED), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array (MEA) recording, Immunohistochemistry and Behavioral tests.